Antibiotics can help eliminate bacterial sinus infections. It takes time to get over sinusitis. Other classes attack the replication cycle of the bacteria, including cell division and protein synthesis needed to reproduce. When you get a cold, also known as an upper respiratory tract infection, should you visit your healthcare provider and get antibiotics? OTC medications that may help include: Decongestants. Accessed Jan. 28, 2020. However, severe, progressive or persistent symptoms might require antibiotics. Years ago, doctors would prescribe antibiotics to treat a bad cold or ear infection to be on the safe side. Patients with any specific questions about this recommendation or their individual situation should consult their physician. KidsHealth from Nemours. If your doctor prescribes an antibiotic, be sure to take the whole course, even after your symptoms get better. Accessed Jan. 27, 2020. This can be taken orally as a pill or liquid. Learn more about the. Emergency Medicine Clinics of North America. The patient is elderly or has a weakened immune system. Mayo Clinic Q and A:Sinusitis and treatment options, Allergy and Sinus Solutions from Mayo Clinic Store, Assortment of Health Products from Mayo Clinic Store, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Could you describe them to me? Centers for Disease Control and Prevention, Antibiotics are defined as any substance that inhibits the growth and replication of a bacterium or kills it outright, according to an. Nasal endoscopy. A healthcare provider will prescribe antibiotics if your infection has spread to your lungs, causing pneumonia. This is because so many strains of staph bacteria have become resistant to other traditional antibiotics. Keep your sinuses hydrated to help relieve pressure. It also discusses over-the-counter treatments and home remedies. Can Essential Oils Treat Sinus Congestion? Carefully pour the saline solution down that nostril. The infection possibly resulted from "sinus rinse practices utilizing tap water," according to a news release from the Florida Department of Health in Charlotte County. It is usually treated with penicillin. Shes previously worked and written for WIRED Science, The Scientist, Discover Magazine, LiveScience, and Business Insider. Levofloxacin is usually only used for bacterial infections that cannot be treated with safer antibiotics. Sinus infections are very common. Sherry Christiansen is a medical writer with a healthcare background. A chronic sinus infection has symptoms that last for 12 weeks or longer. Though aspirin is approved for use in children older than 3, children and teenagers recovering from chickenpox or flu-like symptoms should never take aspirin. Upper respiratory tract infections are usually caused by viruses, like rhinovirus, coronavirus, or influenza, though rarely (about 2% of the time) they are caused by bacteria. It's been suggested that products containing certain combinations of herbs may be of some help. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Learn more about the AAFP support of the Choosing Wisely campaign. Because viral sinus infections tend to improve in 5 to 7 days, healthcare providers will sometimes only prescribe antibiotics if your symptoms go on for longer than this. When your dentist prescribes one of these antibiotics, the choice will depend on whether you are allergic to . Azithromycin contains ingredients that may cause an allergic reaction. Keep your nose 10 inches above the water. In addition, antibiotics have not been found to relieve symptoms or shorten the duration of a cold. This site complies with the HONcode standard for trustworthy health information: verify here. Symptoms of sinusitis include pain, pressure, and tenderness of the areas of the face over the sinuses. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Saline nasal rinses are often used to help flush out thickened mucus and allergens from the nasal passages and to relieve dryness. It may improve the flow of drainage from the sinuses. The infection is treated with a combination of drugs, including the antibiotic azithromycin . He is an assistant clinical professor at the University of California, San Francisco School of Medicine and currently practices at Central Coast Allergy and Asthma in Salinas, California. Do you have any brochures or other printed material that I can take? https://www.womenshealth.gov/menstrual-cycle/your-menstrual-cycle/. If your doctor suspects a bacterial infection, you will be prescribed antibiotics. What are other possible causes for my symptoms? He or she may feel for tenderness in your nose and face and look inside your nose. I recommend starting this early on in the course of the illness to prevent the infection from worsening. 2019;321(19):1946. doi:10.1001/jama.2019.3468, Kenealy T, Arroll B. Egan M, Hickner J. Saline irrigation spells relief for sinusitis sufferers. To alleviate sinus or upper respiratory infections, use eucalyptus oil externally on the temples or chest, or inhaled via a diffuser when the oil is added to boiling water. Antibiotics commonly prescribed to treat staph infections include cefazolin, nafcillin, oxacillin, vancomycin, daptomycin and linezolid. https://www.merckmanuals.com/professional/infectious-diseases/gram-positive-cocci/staphylococcal-infections?query=staph%20infections. Managing a sinus infection? During the day and before bed, use natural saline nasal sprays. Essential oils like eucalyptus and peppermint oils may help open the airways and ease congestion. A sinus infection has similar symptoms to a common cold. Medically reviewed by Drugs.com. Thank you, {{form.email}}, for signing up. Bennett JE, et al., eds. Cefdinir and cephalexin are preferred antibiotics for treating children who have UTIs. Imaging studies. A Cochrane report analyzing the available research into the use of antibiotics to treat colds, published in 2013, found that antibiotics do not work for the common cold, and side effects of antibiotics used for the common cold are common. These problems can include severe allergic reactions, antibiotic-resistant . Children younger than 4 years old: do not use over-the-counter cough and cold medicines in young children unless a doctor specifically tells you to. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. If you are a Mayo Clinic patient, this could Most sinus infections usually get better on their own without antibiotics. Always follow their instructions to achieve the best results. information highlighted below and resubmit the form. Physicians frequently recommend ten to 14 days of amoxicillin or amoxicillin-clavulanate treatment when a person has bacterial sinusitis. J Fam Pract. Use caution when giving aspirin to children or teenagers. Other methods that might be used to diagnose acute sinusitis and rule out other conditions include: Most cases of acute sinusitis get better on their own. https://www.ecfr.gov/cgi-bin/text-idx?SID=76be002fc0488562bf61609b21a6b11e&mc=true&node=se21.4.201_1314&rgn=div8. Sinus infections, and related sinus pressure, can cause toothaches. Cover both your head and the bowl with a thick towel. Most sinus infections are not bacterial, so antibiotics are not necessary. If you or your child is experiencing side effects from a prescribed antibiotic, make sure to tell your healthcare provider to be certain its nothing to worry about. Healthline only shows you brands and products that we stand behind. Cochrane Database Syst Rev. Generally speaking, sinus infections will not go away on their own, and treatment is necessary in order to clear the infection. A doctor may recommend endoscopic sinus surgery if you're experiencing recurrent sinus infections or have a sinus blockage. We include products we think are useful for our readers. Smith SM, Fahey T, Smucny J, Becker LA. If you are a Mayo Clinic patient, this could penicillin. sinusitis, can be either a viral or bacterial infection. While most upper respiratory infections are caused by a virus, you can develop a secondary bacterial infection, like pneumonia, sinusitis, bronchitis, strep throat, or an ear infection. Before your appointment, you may want to make a list that includes: For a staph infection, some basic questions to ask include: Your health care provider will likely ask you a number of questions, such as: If you suspect that you have a staph infection on your skin, keep the area clean and covered until you see your health care provider so that you don't spread the bacteria. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Chronic sinusitis can last for 12 weeks or longer. Doctors may recommend taking antibiotics, which can help alleviate pain and provide symptomatic relief. This drug should only be taken according to your health care providers instructions. Call your doctor if your symptoms dont clear up within 10 days or your breathing is labored. Pediatrics. According to recent research, using a neti pot with a saline solution can get rid of some symptoms of chronic sinusitis. However, they must be used correctly to ensure safety. Risk Factors You should also seek medical care if you have had multiple sinus infections in the past year. What's the best treatment for a staph infection? These self-help steps can help relieve sinusitis symptoms: No alternative therapies have been proved to ease the symptoms of acute sinusitis. Clinical approach to Staphylococcus aureus bacteremia in adults. https://www.uptodate.com/contents/search. congestion. AskMayoExpert. U.S. Department of Health and Human Services. A sinus infection that persists for longer than a week or continues to get worse during this time period is more likely to be bacterial. This drug is also used to treat a wide variety of bacterial infections whichinclude respiratory infections, ear infections, skin infections, and sexually transmitted infections. cephalexin. When did you first notice your symptoms? She has worked in the hospital setting and collaborated on Alzheimer's research. doi:10.1371/journal.ppat.1003057, Baiu I, Melendez E. Epiglottitis. The review found that, in addition to patient-related adverse effects (e.g., skin rash, abdominal pain, vomiting), antibiotic use poses the risk of increased resistance to antibiotics among community-acquired pathogens. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Reye's syndrome. Most sinusitis in the ambulatory setting is due to a viral infection that will resolve on its own. Do I need antibiotics for an upper respiratory infection? Dont stop taking them early, even if your symptoms improve. This content does not have an Arabic version. Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. Current recommendations strongly support not prescribing antibiotics within the first week of illness for mild to moderate sinusitis. Not only is this a big problem for the entire world, but antibiotics can have nasty side effects for the person taking them. Nonspecific upper respiratory tract infection fact sheet, Bosch AATM, Biesbroek G, Trzcinski K, Sanders EAM, Bogaert D. Viral and bacterial interactions in the upper respiratory tract. Amoxicillin rash: When should I be concerned? Your symptoms get worse after initially improving. Mayo Clinic. You have symptoms of a bacterial infection and you have not gotten better after 10 days, even with home treatment. Centers for Disease Control. doi:10.1001/jama.2016.16201, Issa I, Moucari R. Probiotics for antibiotic-associated diarrhea: Do we have a verdict?. There's no treatment for viral sinus infections, but you can manage symptoms with over-the-counter medications. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Nicole Leigh Aaronson, MD, MBA, CPE, FACS, FAAP, Endoscopic Sinus Surgery: The Procedure and Recovery Process. Richmond ENT This drug is usually taken twice a day for more effective results. Also explore types, prevention, and more. While you may first see your family health care provider, you may be referred to a specialist, depending on which of your organ systems is affected by the infection. If you're given an oral antibiotic, be sure to take it as directed. You can even make this at home using 2 cups of water and a 1/2 teaspoon of salt. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Have your symptoms been continuous or occasional? The sinuses are the air-filled pockets in the bones of the face that form the top part of the respiratory tract. by the Microbiology Society. Centers for Disease Control and Prevention. Follow the directions supplied with your specific neti pot. Its important to note that antibiotics are used to treat bacterial infections and will not work for viral infections. When you see your doctor, expect a thorough examination of your sinuses. To provide you with the most relevant and helpful information, and understand which The increase in antibiotic-resistant strains has led to the use of IV antibiotics, such as vancomycin or daptomycin, with the potential for more side effects. Due to recent FDA warnings about joint pain and other issues with fluoroquinolones, such as ciprofloxacin (Cipro) or levofloxacin (Levaquin), this class of drug should be avoided when possible for less serious infections. Is my condition likely temporary or chronic? Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. https://www.cdc.gov/foodsafety/diseases/staphylococcal.html. Other prescription medicines for sinus infection include Cefaclor, Sulfamethoxazole, Azithromycin, Clarithromycin, and Loracarbef. Bacteria that infect the upper respiratory tract are most often S. pyogenes (a group A streptococcus), or sometimes H influenzae. Other home remedies for sinus infections include: Although antibiotics are not always warranted for sinus infections, there are some instances when they can be beneficial. Probably not. The area around your eyes and face might feel swollen, and you might have throbbing facial pain or a headache. Centers for Disease Control and Prevention Antibiotic resistance means that certain drugs no longer work for a specific type of germ. Merck Manual Professional Version. For. Just like Cefaclor, this drug is usually recommended to stop the growth of bacteria. Symptoms lasting more than 10 days without getting better. Saline nasal wash can be a great way to thin out the mucous in the sinuses enough to clear out the blockage. Septra (trimethoprim-sulfamethoxazole) Amoxil (amoxicillin) Symptoms of a Sinus Infection Symptoms of a sinus infection are caused by the blockage of sinuses, which are hollow air spaces in the nasal area. 2009;58(1):29-32. The healthcare provider suspects a bacterial infection and it has spread to other parts of the upper respiratory system, including the pharynx, larynx, or epiglottis, especially when breathing is impacted or in young children. https://naturalmedicines.therapeuticresearch.com. AIDSinfo Apply warm and cold compression alternately to relieve sinus pain and pressure. US emergency department visits for outpatient adverse drug events, 2013-2014. The usual dosage of Cefdinir is a 300 mg tablet twice a day for 5 to 7 days. How can I tell if my infection is getting better or worse? clindamycin. Many varieties have become resistant to one or more antibiotics. A sinus infection, a.k.a. Accessed May 12, 2019. But in many cases, when it comes to the common cold and flu, unnecessary antibiotics may make you feel worse. 3 Antibiotics are used to treat bacterial infections. Daniel More, MD, is a board-certified allergist and clinical immunologist. Sinusitis symptoms typically last no longer than 10 days. Sinusitis is one of the most common diagnoses in primary care. Common causes of chronic sinusitis are: A sinus infection occurs when the tissue in the sinuses swells up. Always follow your pharmacists advice and the guidelines on the package when taking OTC medications. Take your antibiotic as prescribed (especially with food or fluids if indicated). Your doctor can usually make the diagnosis based on the physical exam. JAMA. Healthcare providers typically only prescribe antibiotics for sinus infections that don't clear up on their own. Carefully read and follow instructions on over-the-counter medicine product labels before giving medicines to children. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. A single copy of these materials may be reprinted for noncommercial personal use only. This helps reduce inflammation and swelling. Annually, it accounts for 15% to 20% of adult antibiotic prescriptions and costs more than $20 million in patient visits. Here's what the research says about using essential oils to treat sinus congestion. Below are some ways to help relieve sinus pain and pressure: Ask your doctor or pharmacist about over-the-counter medicines that can help you feel better. Little P, et al. Consult your doctor for more details. Eat healthy foods colorful fruits and veggies that boost your immune system. Whats The Best Way To Get Sinus Pressure Relief Over-the-counter options include nasal decongestants and nasal steroid sprays. A Cochrane review compiled data from 59 studies that involved the use of a variety of antibiotics to manage simple maxillary sinus infection in primary care settings. Cough and cold medicines can result in serious and sometimes life-threatening side effects in young children. Allergists and other specialists recommend limiting the use of antibiotics for situations when the symptoms seem to be caused by a bacterial infection. Renaud DL (expert opinion). These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Get plenty of rest to help your body fight the infection. One study has found that the main ingredient in eucalyptus oil, cineole, helped people with acute sinusitis recover faster. Accessed Feb. 22, 2018. JAMA. How long does doxycycline stay in your body after you finish your prescribed amount? CDC twenty four seven. You doctor may recommend antibiotics if: Most sinus infections usually get better on their own without antibiotics. We avoid using tertiary references. Why are doctors less likely to prescribe antibiotics these days? If a sinus infection is left untreated, it can . If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Hobman TC, ed. Clinical report Fever and antipyretic use in children. Available for Android and iOS devices. You can help prevent sinus infections by doing your best to stay healthy and keep others healthy, including: To receive email updates about this page, enter your email address: We take your privacy seriously. Drink plenty of water To help flush the virus out of your system, make sure you're adequately hydrated. John Carew, MD, is board-certified in otolaryngology and is an adjunct assistant professor at New York University Medical Center. Here's information to help you get ready for your appointment. Antibiotics prescribed for sinusitis include Augmentin (amoxicillin-clavulanate) and cephalosporin. Any given adult will get a cold at least a couple of times a yearusually in the fall and winter. Apparently I had a sinus infection which I think he assumed was bacterial since I had covid 2 weeks ago and he thinks it would've gotten better by now. By Jennifer Welsh What are the alternatives to the primary approach you're suggesting? Have you been around anyone with a staph infection? Learn about treatments to help release the pressure and clear up a toothache. Shigella spreads when infected fecal matter enters another person's mouth or nose, directly or indirectly. What are the antibiotics used for a sinus infection? The overuse of antibiotics is when they are prescribed for reasons other than when they are needed. We've rounded up the seven best decongestants to help relieve your pressure, pain, and congestion. Antibiotics usually aren't needed to treat acute sinusitis, because it's usually caused by a virus and not by bacteria. In some cases, bacteria, or rarely fungus, may cause asinus infection. Do you have any implanted medical devices, such as an artificial joint or a cardiac pacemaker? You can review and change the way we collect information below. These foods contain lots of vitamin C to fight off viruses. Ask your provider what signs and symptoms you should watch for that might mean your infection is getting worse. This content does not have an Arabic version. The Choosing Wisely campaign was created as an initiative of the American Board of Internal Medicine (ABIM) Foundation to improve health care quality. Mayo Clinic. All Rights Reserved. When antibiotics aren't needed, they won't help you, and their side effects could still cause harm. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Several home remedies can help you get rid of a sinus infection unless the cause is bacterial. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Some are common, and others can be severe and potentially deadly. Youll also likely feel stuffed up and have colored snot full of pus. Acute sinusitis: Do over-the-counter treatments help? Sinus infections happen when fluid builds up in the air-filled pockets in the face (sinuses). Viruses cause most sinus infections, but bacteria can cause some sinus infections. Amoxicillin remains the drug of choice for acute, uncomplicated bacterial sinusitis. When and Why You Might Need an Antibiotic for a Cold. Ensure your healthcare provider knows about all other drugs and supplements youre taking. What's the most likely cause of my symptoms? Always use over-the-counter medicines as directed. Put a warm compress over the nose and forehead to help relieve sinus pressure. Antibiotics for Upper Respiratory Infections. Children 4 years or older: discuss with your childs doctor if over-the-counter cough and cold medicines are safe to give to your child. Consult your doctor if you or your child has: If you have a sinus infection for eight weeks or more, or have more than four sinus infections per year, you may have chronic sinusitis. Last updated on March 31, 2022. This interferes with drainage and causes mucus to build up. How long after stopping doxycycline can I drink alcohol? Holland TL, et al. What happens when antibiotics are overused? Most of the time, antibiotics are not indicated for use in treating the common cold or flu. Note that decongestants can help relieve nasal and sinus congestion but they are contraindicated (shouldn't be taken) if you have certain medical conditions, such as glaucoma or hypertension/high blood pressure. Thank you, {{form.email}}, for signing up. 2017;6(6):CD000245. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. What are the symptoms of a sinus infection? Some over-the-counter medicines are not recommended for children of certain ages. azithromycin. Take regular hot showers and breathe in the damp air. 2014. Amoxicillin with clavulanate should be prescribed for patients at high risk of being infected by an organism resistant to amoxicillin. How to treat a sinus infection without antibiotics? Click here for an email preview. American Academy of Allergy, Asthma & Immunology. Most sinus infections don't need antibiotics and will start to get better without treatment. Antibiotics are used to treat bacterial infections. Washing your hands with soap and water. Discover risk factors such as sinus infections. It is a type of antimicrobial designed to target bacterial infections on or within the body. Accessed April 30, 2019. The sinuses are hollow cavities in the bones of your face around your forehead and cheekbones. Strep throat, medically known as streptococcal pharyngitis, is a sore throat caused by infection by streptococcal bacteria. In addition - I often suggest trying saline nose drops or nasal sprays (or a Neti pot), warm compresses and an EarDoc to gently breakup thick mucus in the sinuses and get things moving a bit - plus, it can feel good on the face. You can also fill a bowl with boiling water and lean over it for 10 minutes. information and will only use or disclose that information as set forth in our notice of (1) A meta-analysis published in 2012 in the Archives of Internal Medicine states that some randomized controlled trials showed that patients assigned to antibiotics had a 7% to 14% higher rate of improvement in symptoms. You have had sinusitis for 12 weeks or longer (chronic sinusitis). Yes. This will also help clear the nasal passages from the outside. At Brazos Valley Allergy & Asthma Clinics, we strive to help our patients be as healthy as possible with respect to their allergies, asthma, and immune system. Structural problems within the sinuses. This recommendation is provided solely for informational purposes and is not intended as a substitute for consultation with a medical professional. Overview Acute sinusitis causes the spaces inside your nose (sinuses) to become inflamed and swollen. Microbiology Society Patients with an allergy to penicillin should be prescribed. US emergency department visits for outpatient adverse drug events, 2013-2014. The best (first-line) antibiotics for tooth infection include: amoxicillin. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. When do you need antibiotics for upper respiratory infection? If the cold leads to an ear infection, antibiotics may help resolve it if pain relievers and decongestants dont do the trick. These work by narrowing blood vessels to help reduce inflammation and swelling that cause sinus congestion. Li JTC. Antibiotic use guidelines for children with ear infections differ based on their age and symptoms. https://www.cdc.gov/mrsa/community/environment/laundry.html. When antibiotics arent needed, they wont help you, and their side effects could still cause harm. The most common reason for the visit among children was an adverse reaction to antibiotics. Acute sinusitis: Do over-the-counter treatments help? Three Basic Types Of Inhalers And How To Use It Properly, Urinary Tract Infection and kidney infections. Your allergist or primary care provider will determine whether your sinus infection is caused by bacteria or a virus. Best Antibiotic treatment for sinus infection. Unfortunately, it's hard to know if a sinus infection is bacterial, viral, or has other causes based on symptoms alone. Read on to learn what you can do to support your healing from a sinus infection. Antibiotic-resistant strains of staph bacteria are often described as methicillin-resistant Staphylococcus aureus (MRSA) strains. DOI: 2. 2. Feb. 28, 2022. Your symptoms dont clear up on their own within about 10 days. Theres a line of cold and sinus medications specifically for people with high blood pressure called Coricidin HBP. Information about medical problems you've had, Information about the medical problems of your parents or siblings, All medications, herbs, vitamins and other supplements you take, Questions you want to ask your health care provider. There are a few cases in which antibiotics might be useful: There are a few other reasons you might be prescribed antibiotics for an upper respiratory infection. Reyes syndrome is a very serious, but rare illness that can harm the liver and brain. If you have high blood pressure, consult with your doctor or pharmacist before taking pseudoephedrine. Are there brochures or other printed material I can have? While there are some cases in which you may be prescribed antibiotics for a common cold, these medications aren't harmless. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain, decongestants to remove congestion in the sinuses, and moist heat to relieve pressure can usually help clear up the infection. But complications of colds can occur, including: Some of these complications may require treatment with antibiotics. Sources: AAO-HNSF Updated Clinical Practice Guideline: Adult Sinusitis (Affirmation of Value by the AAFP). Depending on the type of antibiotic, they may be taken from 3 to 28 days. Ahovuo-Saloranta A, Rautakorpi U-M, Borisenko OV, et al. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.
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